Current Science

V. S. Prasad ¹, C. J. Johny ¹, P. Mali ¹, Sanjeev Kumar Singh ¹, E. N. Rajagopal ¹

Affiliations
1 National Centre for Medium Range Weather Forecasting, A-50 Secto-62, Institutional Area, Noida 201 309, IN

Abstract

The National Centre for Medium Range Weather Forecasting (NCMRWF) conducted its first global data retrospective analysis (reanalysis) for the period 1 January 2000-31 March 2011 using its GFS based system (NGFS). This reanalysis is called NGFS-R and the main objectives of this effort are to address issues for studying decadal variability of the Indian summer monsoon, high-resolution global analysis fields to study the Indian monsoon and to provide short-term mean fields for its seasonal/long-term forecasts by ensemble methods. NGFS-R has been conducted with the T574L64 version of the Global Data Assimilation and Forecasting System of NCMRWF that is operational as of May 2015, and using CFS-reanalysis data dump. With this effort, a high-resolution global data analysis at 6 h intervals is made available for about 16 years (2000-2015) for various uses and applications.

Keywords

Global Data Assimilation and Forecasting, Monsoon Season, Numerical Weather Prediction Models, Retrospective Analysis.

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Prassan Choudhary ¹, Hillol Chakdar ¹, Dikchha Singh ¹, Chandrabose Selvaraj ², Sanjeev Kumar Singh ², Sunil Kumar ³, Anil Kumar Saxena ¹

Affiliations
1 ICAR-National Bureau of Agriculturally Important Microorganisms, Kushmaur, Mau 275 103, IN
2 Department of Bioinformatics, Alagappa University, Karaikudi 630 003, IN
3 Centre for Agricultural Bioinformatics, ICAR-Indian Agricultural Statistics Research Institute, New Delhi 110 002, IN

Abstract

In this study, we screened 26 bioactive compounds present in various spices for activity against SARS-CoV-2 using molecular docking. Results showed that piperine, present in black pepper had a high binding affinity (–7.0 kCal/mol) than adenosine monophos-phate (–6.4 kCal/mol) towards the RNA-binding pock-et of the nucleocapsid. Molecular dynamics simulation of the docked complexes confirmed the stability of piperine docked to nucleocapsid protein as a potential inhibitor of the RNA-binding site. Therefore, piperine seems to be potential candidate to inhibit the packag-ing of RNA in the nucleocapsid and thereby inhibiting the viral proliferation. This study suggests that consumption of black pepper may also help to combat SARS-CoV-2 directly through possible antiviral effects, besides its immunomodulatory functions.

Keywords

Binding Affinity, Black Pepper, COVID-19, Homology Modelling, Piperine.

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